Infection of SJL/J mice with the lactate dehydrogenase virus resulted in a greater increase in the plasma activities of lactate dehydrogenase, malate dehydrogenase, and isocitrate dehydrogenase than expected from findings with other inbred strains. Evidence is presented to suggest that the differences are due to an exaggerated reduction in the clearance of these enzymes. It is postulated that the data signify a deficiency in the function of the reticuloendothelial system of SJL/J mice. 178 C.G. C~ise~NS, JR.: colony that has since been maintained, by brother and sister rantings, in our Animal Services Center. Most of the experiments utilized male as well as female animals, 8 to 12 weeks old. However, except for the initial studies on plasma LDH levels, only data obtained from female mice will be reported. Strain BALB/c mice of the same ages and of both sexes were used for controls. These were supplied, as needed, through the courtesy of Dr. CEARLnS P. DAGG. None of the animals had reticulum cell neoplasms at autopsy, which was never later than 16 weeks of age.

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