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The diabetogenic variant of encephalomyocarditis virus (EMC-D) induces a diabeteslike syndrome in certain strains of mice. A study was done to determine if virus-induced diabetes could be prevented by interferon (IFN). It was found that the production of diabetes by EMC-D was blocked by either IF", or a variety of IFN-inducers in SWR/J, but not ICR Swiss mice. The replication of EMC-D in cell culture was inhibited by IFN,. It is concluded that the response of pancreatic beta cells to the protective effect of IFN, is probably under genetic control.

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