Serum levels of propylthiouracil were measured in 8 normal persons and in 7 patients with hyperthyroidism after a single, 300 mg, oral dose of 6-n-propyl-2-thiouracil (PTU). The patients with hyperthyroidism were restudied after 3, 6, and 9 weeks of individualized treatment with PTU. The serum half-life of the drug in normal subjects was 1.65 h. In patients with hyperthyroidism the serum half-life was similar, and it did not change significantly as the euthyroid state was achieved.

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An automated determination of glucose with o-toluidine is described. Microquantities (0.04 ml) of plasma or serum are added directly to one reagent, without dialysis, to produce a green color that follows Beer’s law over a wide range of concentrations. This method compares favorably with a manual o-toluidine procedure.

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