Our results indicate that the MMP7 promoter genotypes only play an indirect role in determining the personal susceptibility to oral cancer in Taiwan.

The MMP1 -1607 1G allele is a non-significant protective biomarker for lung cancer in Taiwan.

Optical beam-induced current (OBIC) mapping is widely used to characterize semiconductor lasers, particularly for failure analysis, in which the reliability has been a critical issue to be resolved spectrally and temporally. OBIC microscopy is advantageous for its non-invasiveness, when compared with electron beam-induced current (EBIC) microscopy. However, for high-speed devices, conventional OBIC methods may be limited in observing the spectral responses adequately. In this work, we present a modified OBIC microscopy based on a tunable ultrafast laser, to address the need for spectral resolving for precision failure spot analysis in vertical-cavity surface-emitting laser (VCSEL) diodes. The spectral OBIC response of VCSEL diodes is investigated by varying the irradiation wavelengths. Importantly, the ultrafast mode-locked laser provides broadband wavelength range to investigate photocurrent responses of the VCSELs sample. Specifically, the OBIC, electroluminescence (EL) detection, and the reflectance of the normal and the electrostatic discharge (ESD) damaged VCSELs are compared. We have found the ESD damaged VCSELs showing a redshifted spectral response.

Background/Aim: Oral cancer incidence is highest worldwide in Taiwan, and practical markers for personalized therapeutic strategies such as immunotherapies, is lacking. Interleukin-12 (IL12) is a cytokine that is reported to exhibit potent tumoricidal effects, however, its genotypic contribution to oral cancer is still largely unknown. We aimed to examine whether IL12A rs568408 and rs2243115 genotypes are associated with oral cancer risk in Taiwan. Materials and Methods: Genotypic characteristics of IL12A were determined among 958 oral cancer cases and age-and gender-matched individuals via typical polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The variant genotypes of IL12A rs568408 and rs2243115 were not found to be significantly associated with elevated oral cancer risk (all p>0.05). Moreover, there was no interaction between IL12A genotypes and personal smoking, alcohol drinking and betel quid chewing behaviors (all p>0.05). Conclusion: IL12A rs568408 and rs2243115 genotypes may not serve as good predictors for oral cancer risk.