Low-intensity pulsed ultrasound (LIPUS) has also been reported to improve behavioral functions in Parkinson’s disease (PD) animal models; however, the effect of LIPUS stimulation on the neurotrophic factors and neuroinflammation has not yet been addressed. PD rat model was built by injection of 6-hydroxydopamine (6-OHDA) in 2 sites in the right striatum. The levels of neurotrophic factors and lipocalin-2 (LCN2)-induced neuroinflammation were quantified using a western blot. Rotational test and cylinder test were conducted biweekly for 8 weeks. When the 6-OHDA + LIPUS and 6-OHDA groups were compared, the locomotor function of the 6-OHDA + LIPUS rats was significantly improved. After LIPUS stimulation, the tyrosine hydroxylase staining density was significantly increased in the striatum and substantia nigra pars compacta (SNpc) of lesioned rats. Unilateral LIPUS stimulation did not increase brain-derived neurotrophic factor in the striatum and SNpc of lesioned rats. In contrast, unilateral LIPUS stimulation increased glial cell line-derived neurotrophic factor (GDNF) protein 1.98-fold unilaterally in the SNpc. Additionally, LCN2-induced neuroinflammation can be attenuated following LIPUS stimulation. Our data indicated that LIPUS stimulation may be a potential therapeutic tool against PD via enhancement of GDNF level and inhibition of inflammatory responses in the SNpc of the brain.

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The occupational injury death rate and mortality ratio owing to cerebrovascular and cardiovascular diseases in the construction industry are the highest among all industries in Taiwan. Reducing work stress and improving safety behavior is a must for reducing occupational disasters and diseases. Construction site management personnel’s safety behavior is an important paradigm for construction workers. This study explored the relationships among work stress, safety behavior, professional identity, social status perception, and social support for construction site management personnel by using structural equation modeling (SEM). The results indicated that low work stress can lead to favorable safety behavior. Greater company support, family support, and professional identity reduce work stress. Social status perception negatively influences work stress indirectly through the mediation of professional identity. The results revealed that construction site management personnel working within an exempt employee system (i.e., no overtime pay and compensatory leave) exhibited a significantly higher effort/reward ratio than those without this system. Gender, headquarter location, and site location also significantly influenced the on-site management personnel’s effort/reward ratio.

No abstract