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Special AT-rich sequence binding protein 2 (SATB2), a nuclear matrix attachment region-binding protein, can regulate embryonic development, cell differentiation, and cell survival. Previous studies showed that SATB2 is involved in osteoblast differentiation and skeletal development. In this study, we evaluated the role of SATB2 in oxidative stress-induced apoptotic insults to human osteoblast-like MG63 cells and mouse MC3T3-E1 cells. Exposure of MG63 cells to menadione increased intracellular reactive oxygen species levels in a concentration-and time-dependent manner. Simultaneously, menadione-induced oxidative stress triggered cell shrinkage and decreased cell viability. In addition, treatment of MG63 cells with menadione time-dependently decreased the mitochondrial membrane potential but enhanced caspase-3 activity. As a result, menadione-induced DNA fragmentation and cell apoptosis. As to the mechanism, exposure of MG63 cells to menadione amplified SATB2 messenger (m)RNA and protein expression in a time-dependent manner. Knockdown of translation of SATB2 mRNA using RNA interference led to chromatin disruption and nuclear damage. When MG63 cells and MC3T3-E1 cells were treated with SATB2 small interfering RNA, menadione-induced cell apoptosis was increased. We conclude that menadione causes oxidative stress in human osteoblasts and induces cellular apoptosis via a mitochondrion-caspase protease pathway. In addition, SATB2 may play a crucial role in protecting against oxidative stress-induced osteoblast apoptosis. ß

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A low power consumption and high gain ultra-wide-band (UWB) low noise amplifier (LNA) utilizing a common-gate stage connected with a common-source stage by using current-reused structure is proposed. The implemented LNA exhibits a maximum power gain of 14.2 dB with a total (core) power consumption of 7.2 mW (3.8 mW) under a 1.5 V power supply. A minimum noise figure of 4.1 dB was obtained within 3-dB bandwidth of 2.7-8.2 GHz. The proposed UWB LNA presents the highest ratio of the power gain to power consumption among the compared papers. ABSTRACT: An improved wideband planar inverted-F antenna (PIFA)is investigated in this work. The meander line structure is introduced into the conventional PIFA and significant bandwidth improvement can be observed. Two improved PIFA antennas with different meander line structures are designed and fabricated; the measured results show good agreement with the simulations, demonstrating 23.1 and 40% bandwidth at Ϫ10 dB return loss, about 131 and 300% bandwidth enhancement, respectively, compared with the original PIFA (less than 10%). Obviously, the proposed antenna demonstrates good performances (especially in bandwidth), compact size, low profile, and low cost; it is thus expected to find possible applications in wireless communication systems.

<p>The landslide prone area, Xingzhuang has been identified as a deep-seated landslide prone area by Taiwan authorities. Where covers a 10.3 hectares’ area with an average slope of 22.8 degrees and 20 buildings around the slope toe. The majority lithology of upper slope is sand-shale interbedded with highly sand contented, which differs from lower slope in shale with mud contented. In order to grasp the activities of this area, we have installed a real-time compound monitoring station including GNSS, biaxial tiltmeter, ground water level meter, and rain gauge.</p><p>The rainfall depth of 2021 and 2022 was 4,175 mm and 1,691 mm respectively. The difference was larger than 2400 mm in our study area which might induced the different activity behaviors. In this study, we discussed the relations of slope activity and hydrological parameters in last two years. The results show (1) The variation of X-direction of tiltmeter were about 7,500 and 3,500 (sec) in 2021 and 2022, respectively. The variation of Y-direction of tiltmeter were about 6,500 and 4,500 (sec) in 2021 and 2022, respectively. (2) In the same 6-hours rainfall intensity, the 6 hours tilt-angle of X and Y direction in 2021 were both two times of 2022. (3) In the same ground water level, the 6 hours tilt-angle of X and Y direction in 2021 were about 2 and 1.5 times of 2022, respectively. (4) In the same variation of 6-hours ground water level, no matter raising or decline ground water level the 6 hours tilt-angle of X and Y direction in 2021 were about 2.2 and 1.5 times of 2022, respectively. And the change rate of the 6 hours tilt-angle would be accelerated when the 6-hours variation of groundwater level was higher than 0.4 meters. On the whole, the rainy year would induce more active than dry year.</p>