<p>Transcription factors that could potentially bind to the promoter region of TIMP3 estimated by HOCOMOCO (A) and JASPAR2018 (B)</p>

<p>Differentially expressed genes between ccRCC patients with normal blood pressure and hypertension in bulk RNA-seq (A) and scRNA-seq (B), and Genes with higher expression levels in endothelial cells than other cells (C)</p>

<p>Top 100 genes that have similar expression patterns with TIMP3 in ccRCC by GEPIA2</p>

<p>Supplementary Figure 2 shows the efficiency of endothelial cell depletion in immunomagnetic cell separation, and TIMP3-overexpression in HUVECs suppressed the growth of 786O cancer cells implanted in the subcutaneous tissue of nude mice.</p>

<p>Differentially expressed genes between ccRCC patients with normal blood pressure and hypertension in bulk RNA-seq (A) and scRNA-seq (B), and Genes with higher expression levels in endothelial cells than other cells (C)</p>