Analogs of antisense or antigene oligodeoxyribonucleotides are of interest as potential antiviral, antibacterial, and anticancer agents.1-4 Much recent research has shown that though the selective modulation of gene expression is certainly feasible, the exact mechanistic role of interfering oligonucleotides remains uncertain.5-7 Both research and potential therapeutic applications, however,

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The Synthesis of Modified Achiral Internucleoside Linkages: -NHCH2CH2-Linked Oligonucleosides.-A methodology for the preparation of oligonucleotides uniformly bridged with the N-C-C internucleoside linkage is described with the synthesis of the completely protected thymidylate trimer (X). The bifunctional synthon (IV) derived from the azidothymidine (I), the 7'-aldehyde (V), and the aminothymidine (VIII) represent the key building blocks. -(SAHA, A. K.; SCHAIRER, W.; WAYCHUNAS, C.; PRASAD, C. V. C.; SARDARO, M.; UPSON, D. A.; KRUSE, L. I.; Tetrahedron Lett.

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