Alkylenedithiophosphate derivatives of macrocyclic complexes of Pb (II), having N4S4 potential donors, of the general formula, [Pb(L){S2P(OR)2}2] where L=macrocyclic ligands L1, L2, L3, L4 and L5; R= C2H5-, C3H7n or C3H7i have been synthesized from the reaction of [Pb(L)X2(where X= Clˉ, NO3ˉ or CH3COOˉ) with sodium Alkylenedithiophosphate in 1:2 molar ratios in THF. These complexes have been characterized by elemental analysis, molar conductance, molecular weight determinations, IR, 1H, 13C NMR. Macrocyclic Complexes of Pb (II) derivatives have been studied by screening them Aspergillus flavus, Fusarium oxysporum, Alternaria alternata and bacteria like Salmonella typhi and Bacillus subtili. Alkylenedithiophosphate derivatives were found to be more fungitoxic and antibacterial than their corresponding macrocyclic complexes.