Introduction: Blood is essential for life. It contains cellular component and plasma which supplies oxygen, nutrients to different parts of the body. Transfusion of blood and blood components is an integral part of health care practice. Many a times there will be injudicious use of blood and its products among patients which causes unnecessary burden to the patients as well to blood bank. Main aim of this study is to evaluate the pattern utilization of blood and blood components in Karnataka institute of medical sciences. Materials and methods:This was retrospective study carried out over a period of 1 year from January 2015 to December 2015. Necessary data were collected from blood bank registers. Results:Total blood units collections were 13,378. Units utilized were 12,555. Whole blood was the most utilized product followed by PRBC, FFP and least utilized product was platelet concentrates. Gynaecological wards were the Major benefited from the blood supply in this study. Conclusion:Formulation of strict guidelines for transfusion practices will improve the appropriate use of precious resource. Periodic evaluation of utilization pattern, demand for different blood products also helps to maintain the blood stock.