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In this study, we propose a modified gold nanoparticle-graphene oxide sheet (AuNP-GO) nanocomposite to detect two different interactions between proteins and hybrid nanocomposites for use in biomedical applications. GO sheets have high bioaffinity, which facilitates the attachment of biomolecules to carboxyl groups and has led to its use in the development of sensing mechanisms. When GO sheets are decorated with AuNPs, they introduce localized surface plasmon resonance (LSPR) in the resonance energy transfer of spectral changes. Our results suggest a promising future for AuNP-GO-based label-free immunoassays to detect disease biomarkers and rapidly diagnose infectious diseases. The results showed the detection of antiBSA in 10 ng/ml of hCG non-specific interfering protein with dynamic responses ranging from 1.45 nM to 145 fM, and a LOD of 145 fM. Considering the wide range of potential applications of GO sheets as a host material for a variety of nanoparticles, the approach developed here may be beneficial for the future integration of nanoparticles with GO nanosheets for blood sensing. The excellent anti-interference characteristics allow for the use of the biosensor in clinical analysis and point-of-care testing (POCT) diagnostics of rapid immunoassay products, and it may also be a potential tool for the measurement of biomarkers in human serum.Electronic supplementary materialThe online version of this article (10.1186/s11671-018-2565-7) contains supplementary material, which is available to authorized users.

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In this paper, we're binding gold nanoparticles (GNPs) and reduced graphene oxide (rGO) by cystamine (Cys). The PEDOT:PSS mix GNPs/Cys/rGO as a hole transport layer of the solar cell. From the experimental result shows the PEDOT:PSS/GNPs/Cys/rGO/ITO film than ITO film have the best transmittance. It's transmittance was decreased for 1.01% at 545 nm wavelength. The sheet resistance of PEDOT:PSS/GNPs/Cys/rGO/ITO was reduce than PEDOT:PSS/ITO, when it was doped with Gold nanoparticles (GNPs) and rGO on ITO glass. The former is than the latter decreased for 1%. For these reasons due to impact by surface doping of composite plasmonic material.