Five new benzophenone derivatives, 13,14-didehydoxyisogarcinol (1), garcimultiflorone A (2), garcimultiflorone B (3), 13-hydroxygarcimultiflorone B (4), and garcimultiflorone C (5), have been isolated from the fruits of Garcinia multiflora, together with seven known compounds (6-12). The structures of these new compounds were determined through spectroscopic and MS analyses. 13,14-Didehydoxyisogarcinol (1), garcimultiflorone A (2), garcimultiflorone B (3), and 13-hydroxygarcimultiflorone B (4) exhibited inhibition with an IC(50) range of 0.11-5.58 microM on superoxide anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B (fMLP/CB).

Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5–17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3–6, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 μg/mL.

A novel benzoylphloroglucinol derivative, garcimultiflorone D (1), with an unusual adamantyl-caged skeleton was isolated from the fruits of Garcinia multiflora, together with four known compounds. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Garcimultiflorone D (1) exhibited inhibitory activities with IC(50) values of 7.21±1.07 and 6.01±0.37 μg/ml against fMLP/CB-induced superoxide anion generation and elastase release, respectively.