Commonly available analgesics, such as paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs), are used widely with few or no adverse events by most individuals. However, some adverse events have been observed following the use of these drugs. This paper reports a case of paracetamol and NSAID-induced seizures in a patient with the human immunodeficiency virus infection/acquired immune deficiency syndrome (HIV/AIDS). These seizures occurred at different times, first with paracetamol and then diclofenac (a NSAID). She was concurrently on anti-retroviral drugs and