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A new biomaterial containing polyvinyl alcohol foam with a fully open-cell microstructure would be designed and prepared via air-foaming procedure in this study. The resulting biomaterials might provide several functional properties for various clinic potential applications. Also, the resulting biomaterial containing polyvinyl alcohol foam could be employed to prepare a series of new medical device for the clinic potential applications. Further, a systematic design-thinking method for innovative design of medical device would be built up and provided. A series of new medical devices would be designed and obtained.

A new regenerative collagen particle with extra-cellular matrix (ECM) was designed and prepared from porcine dermal. A specific tissue-cutting machine was designed to prepare extra thin tissue membranes, which could be used for preparing the regenerative collagen particles with ECM. Furthermore, a novel procedure combining supercritical carbon dioxide fluids technology and protease treatments at low temperatures was employed. Characteristics of the resulting regenerative collagen particles with ECM were observed by determining morphology, thermal property and mechanical property for clinic application of medical devices

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