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SUMMARYA 7-year-old female Toy Poodle weighing 2 .1 kg showed joint swelling and angular deformity with pain and lameness. Radiography revealed luxation with severe destruction of joints and periarticular soft tissue swelling. Hyperglobulinemia with increased levels of alpha2 , beta and gammaglobulin fractions was observed. After administrating of bucillamine, an immunomodulator , clinical signs of affected joints were significantly improved in accordance with decreasing gamma globulin , suggesting that immunologic mechanism might be involved in this case of canine rheumatoid arthritis .