Background: Cutaneous Adverse Drug Reaction (CADR) is a reaction that can cause changes in the structure, the function of the skin, and mucous membranes caused by drug use. One of the risk factors of CADR is a comorbid disease. Objective: to determine the relationship between comorbid diseases and the severity of Cutaneous Adverse Drug Reaction (CADR) at Dr. Saiful Anwar Hospital, Malang. Methods: This study used secondary data taken from medical records of skin and genital patients at Dr. Saiful Anwar Hospital Malang in 2018-2020 and was analyzed using SPSS software version 23 with the Chi-Square test method to determine the significance of the relationship between variables. Result: This study was conducted on 167 patients with mild CADR (52.7%) more than severe CADR (47.3%). The most frequently experienced mild and severe CADR was exanthematous drug eruption and DRESS. In addition, there were also 68 CADR patients with the comorbid disease (40,7 %). Seen from the statistical tests performed, obtained p-value = 0.074 and Odds Ratio (OR) = 1.861. Judging from the p-value, it can be concluded that there is no significant relationship between comorbid disease and the severity of CADR (p > 0.05). Despite that, when viewed from the OR results, it shows that patients with comorbid diseases have a statistically higher risk of 1.861 times higher of experiencing the mild type of CADR than the severe type. Conclusion: One to suggest for this research is to collect medical record data within a longer time span. It is expected that the data is complete and as needed so that it can support the shortcomings in this study.