BACKGROUND<br />Hypertension is the main cause of morbidity and mortality associated with cardiovascular diseases. Many herbs/spices appear to have significant effects in favorably modulating high blood pressure. A jamu formulation containing 6 plant extracts, Formula Jamu Antihipertensi (FJA), has been described previously. This research study aimed to evaluate the effect of FJA as antihypertensive agent in mild to moderate hypertensive patients. <br /><br />METHODS<br />This double-blind experimental study was conducted in 40 hypertensive patients, who were randomized into two groups. The first group was treated with oral administration of 2 g FJA and the second group 25 mg captopril daily for 4 weeks. Systolic and diastolic blood pressure as well as liver and kidney function were followed up every week. Independent- t test and two-way ANOVA were used to analyze the data with a level of significance of 0.05.<br /><br />RESULTS<br />The results showed that after the treatment, FJA and captopril were capable of significantly decreasing systolic and diastolic blood pressure (p &lt;0.05). The decrease in systolic blood pressure between the two groups was identical (p&gt;0.05), while the decrease in diastolic blood pressure was greater in the FJA group than in the captopril group (p &lt;0.05). <br /><br />CONCLUSION<br />From this study it may be concluded that administration of FJA for 4 weeks is equally effective as captopril in reducing systolic and diastolic blood pressure in patients with mild and moderate hypertension. Thus, natural plants and herbs can be our source of drugs, with fewer side effects and better bioavailability for treatment of hypertension in the future.

The study's purpose was to obtain the concept of the value of local wisdom in the digital era with the existence of an independent learning policy on an independent campus. This study analyzed all research data related to the value of local wisdom and MBKM that has been carried out by previous researchers. This study was a literature review research through a qualitative approach. The research data was taken from research results that have been published in national and international journals in the period 2010-2022. The data analysis stage used in this study was a qualitative approach which includes: data reduction, data presentation, and conclusion. The results of this study resulted in the concept of applying local wisdom values that were compatible with the application of the MBKM policy and were also related to advances in digital technology with all the demands for quality human resources. Educators and educational institutions must work together to develop local wisdom values in MBKM policy-based learning. Educators can use the results of this research as theoretical input for developing learning facilities

Mesenchymal stem cells (MSCs) are multipotent stromal cells that have the capacity to regenerate tissue damage. However, they have several limitations. MSC-CM as a new approach treatment is widely used to solve the limitation of MSC in wound healing. The aim of this study was to evaluate the effectiveness of TNF-α-activated MSC-CM topical gel compare to topical-subcutaneous injection combination on wound healing acceleration. This study was conducted between April-August 2018 at the

Essay writing has a fairly complex level of difficulty. Moreover, the online and offline learning process in the era of technological progress has directed learning activities to be carried out through technological innovation. The purpose of this study was to determine the impact of film trailers on improving English essay writing skills for students at Bina Sarana Informatika University, Jakarta. The research method uses experiments with a one-group experimental design. Participants were taken using a purposive sampling technique of as many as 50 students. The research was conducted on 3rd-semester students of the 2021-2022 academic year. The data analysis technique used essay tests and observation. Data were analyzed using a t-test. The results showed that students in the Essay Writing class experienced an increase in their ability to write English essays. There are 80% of the respondents who experienced an increase in their English essay writing test scores before and after using the film trailer learning media. In addition, the data from the t-test also showed that t-Stat t-table (-10.384 2.0095), meaning that there was a significant effect of movie trailers on English essay writing skills. The results of the study also have implications for the understanding of the teaching staff regarding the use of digital learning media or technology applications in building more innovative writing classes

The purpose of this study was to analyze the influence of individual factors and organizational factors on the cyberloafing behavior of employees at the Malang City Education and Culture Office. Data was collected by census through questionnaires distributed online via google form. Multiple linear regression analysis, proves that individual factors from work stress and organizational factors from the work environment have a positive and significant effect on cyberloafing behavior. For this reason, in order to reduce the cyberloafing behavior of its employees, the Malang City Education and Culture Office must have a written rule that prohibits its employees from carrying out cyberloafing activities during working hours, because this is very important so that employees do not arbitrarily carry out cyberloafing activities. it needs to be accompanied by sanctions.