Catalytic hydrodechlorination (HDC) is an innovative means of transforming chlorinated waste streams into a recyclable product. Hydrodehalogenation of 4-tert-butyl-1-chloro-2-nitrobenzene over Raney nickel catalyst has been investigated. The influence of different parameters, such as reaction solution, bases type, temperature and pressure are explored. Using Raney nickel as catalyst, methanol and water (v: v=4:1) as the reaction solution, ammonium acetate as the addictive, the ratio of ammonium acetate and 4-tert-butyl-1-chloro-2-nitrobenzene is 1:1, temperature 140 °C and pressure 3.0 Mpa, the highest efficiency can be achieved on hydride-chlorination of 4-tert-butyl-1-chloro-2-nitrobenzene. We find that a rather high catalytic activity can be retained by adding water.