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Abstract. Reliable precipitation data are highly necessary for geoscience research in the Third Pole (TP) region but still lacking, due to the complex terrain and high spatial variability of precipitation here. Accordingly, this study produces a long-term (1979–2020) high-resolution (1/30∘, daily) precipitation dataset (TPHiPr) for the TP by merging the atmospheric simulation-based ERA5_CNN with gauge observations from more than 9000 rain gauges, using the climatologically aided interpolation and random forest methods. Validation shows that TPHiPr is generally unbiased and has a root mean square error of 5.0 mm d−1, a correlation of 0.76 and a critical success index of 0.61 with respect to 197 independent rain gauges in the TP, demonstrating that this dataset is remarkably better than the widely used datasets, including the latest generation of reanalysis (ERA5-Land), the state-of-the-art satellite-based dataset (IMERG) and the multi-source merging datasets (MSWEP v2 and AERA5-Asia). Moreover, TPHiPr can better detect precipitation extremes compared with these widely used datasets. Overall, this study provides a new precipitation dataset with high accuracy for the TP, which may have broad applications in meteorological, hydrological and ecological studies. The produced dataset can be accessed via https://doi.org/10.11888/Atmos.tpdc.272763 (Yang and Jiang, 2022).

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Alendronate is an antiosteoporotic drug that targets the mevalonate pathway. To investigate whether the genetic variations in this pathway affect the clinical efficacy of alendronate in postmenopausal Chinese women with osteopenia or osteoporosis, 23 single-nucleotide polymorphisms (SNPs) in 7 genes were genotyped in 500 patients treated with alendronate for 12 months. Bone mineral density (BMD) was measured at baseline and after 12 months. The rs10161126 SNP in the 3' flanking region of MVK and the GTCCA haplotype in FDFT1 were significantly associated with therapeutic response. A 6.6% increase in BMD in the lumbar spine was observed in the GG homozygotes of rs10161126; AG heterozygotes and AA homozygotes experienced a 4.4 and 4.5% increase, respectively. The odds ratio (95% confidence interval) of G allele carriers to be responders in lumbar spine BMD was 2.06 (1.08-6.41). GTCCA haplotype in FDFT1 was more frequently detected in the group of responders than in the group of non-responders at the total hip (2.6 vs 0.5%, P=0.009). Therefore, MVK and FDFT1 polymorphisms are genetic determinants for BMD response to alendronate therapy in postmenopausal Chinese women.