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The reduction by CO of diaquo-cobinamide, diaquo-cobyric acid and several complete aquocorrinoids in aqueous solutions was studied. Aquo-cobalamin-lactam and all the other corrinoids under study were reduced to (CoII). At 37°C the reaction is about two to three times faster than at 22°C, and it is inhibited by benzimidazole and (more strongly) by histidine. CO is a better reductans for diaquo-cobinamide and diaquo-cobyric acid than for the complete corrinoids. Corrinoids with a purine base are more quickly reduced than those with a benzimidazole base. The experiments show that the reaction of CO with corrinoids is inhibited or delayed by those trans ligands, which are strong electron donors.

No abstract