Sporotrichosis is a subcutaneous mycosis caused by Sporothrix schenckii complex. The disease has been reported worldwide. However, the incidence of the etiological agent varies in its geographic distribution. We studied 39 clinical isolates of Sporothrix schenckii from diverse regions in Mexico, collected from 1998 to 2016. Molecular identification was performed by sequence analysis of the partial calmodulin gene. In vitro antifungal susceptibility to amphotericin B (AMB), itraconazole (ITC), voriconazole (VRC), posaconazole (PSC), fluconazole (FLC), terbinafine (TRB), caspofungin (CSF), anidulafungin (ANF), and micafungin (MCF) was evaluated. Thirty-eight isolates of S. schenckii complex were divided into five supported clades in a phylogenetic tree. The predominant clinical form was lymphocutaneous (92.3%), fixed cutaneous (5.1%), and disseminated (2.5%). Terbinafine exhibited the best in vitro antifungal activity, while fluconazole was ineffective against Sporothrix schenckii complex. Our results showed diverse geographic distribution of clinical isolates in eight states; definitive identification was done by CAL gen PCR-sequencing. In Mexico, S. schenckii is considered to be an etiological agent of human sporotrichosis cases, and lymphocutaneous is the most prevalent form of the disease. This study revealed four clades of S. schenckii sensu stricto by phylogenetic analysis. Furthermore, we report one case of S. globosa isolated from human origin from the North of Mexico.

Candidíase é a doença fúngica mais comum e, geralmente, ocorre como infecção oportunista em doentes debilitados. Atinge as membranas e a pele humana, porém, a sua simples presença no organismo não significa doença.O agente mais freqüente de candidíase é a Candida albicans seguida por C. tropicalis, C. A deficiência de vitaminas A e D propiciaria o aparecimento de candidíase mucocutânea e, eventualmente, sistémica em indivíduos idosos. A candidemia ocorre em condições iatrogênicas e/ ou debilitantes7 8 9111213141516; não há evidência clínica de infecção e o quadro evolutivo é insidioso e inespecífico a exemplo, da candidíase invasiva nos portadores de síndrome de imunodeficiência humana (AIDS).As portas de entrada, a saber: orofaringe, cateter intravenoso e a contaminação de sangue humano em seringas favorecem a invasão do agente fúngico no organismo. A endocardite pode surgir, principalmente, após cirurgia de