Background: In Chile we also consider surgery as a treatment in the hepatic metastases of colorectal cancer. We present the first series that measures the Chilean genetic profile. Methods: We reviewed the clinical records of all colorectal cancers operated in our center from 2005 to the present. Conclusion: We found a RAS mutation is very common in our population. Which is a bad genetic factor in our population. P 219 CEPHALIC DUODENOPANCREATECTOMY RESECTION: TECHNIQUE, MORBIDITY AND MORTALITY

Background: In the year 2007 a group of experts come together to discuss criteria for acute cholecystitis and to establish therapeutic guidelines and states of gravity in this disease. Objectives: we correlated the criteria of the Tokyo Guidelines 2007 with the anatomopathology study of the surgical specimen. Setting: Service of Urgencies of the National Clinic Hospital in Córdoba, Argentine. Methods: We studied 324 patients (120 male and 204 female) older than 15 years and without limits of age with the criteria of acute cholecystitis a cord to the Tokyo guidelines 2007. 202 patients had a preoperative diagnosis of chronic cholecystitis and 89 of acute cholecystitis, all received cholecystectomy and studied the operative specimen in the anatomopathology department. Anatomopathology criteria for acute cholecystitis were the presence of polimorpho nuclear cells (PMN), for acute exacerbation of chronic cholecystitis the presence of PMN and monomorpho nuclear cells (MN), and for chronic cholecystitis the presence of MN with or without fibrosis. Results: This work showed 82,14% of sensitivity for the diagnostic criteria of Tokyo guidelines, 74,03% of specificity, and positive predictive value of 46%. With the Bayes Theorem the predictive value in Córdoba city was 18,49%. Conclusion: There is an important difference in the specificity and positive predictive value between our work and the Tokyo guidelines for acute cholecystitis. There is an important group of patients in our work with acute exacerbation of chronic cholecystitis that is not classified in the diagnostic criteria for acute cholecystitis of Tokyo guidelines. Keywords: Tokyo guidelines 2007, acute cholecystitis, chronic cholecystitis, acute exacerbation of chronic cholecystitis, pathology study of the specimen. ArTICULO OrIGINAL revista de la Facultad de Ciencias médicas 2017; 74(2):88-92