Background:The superior olivary complex (SOC) is an essential center for spatial hearing. Results: Generation of a comprehensive qualitative and quantitative catalogue of the developmental changes in the SOC-related gene repertoire. Conclusion: Postnatal maturation of the SOC is shaped by extensive molecular changes. Significance: This work identifies strong candidate genes for normal and impaired hearing and genetic evidence for retrocochlear functions of deafness genes.

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The metabolism of nitrogen‐rich nucleosides in Arabidopsis seedlings was investigated at the level of import and subsequent salvage or degradation. Uptake and fate of nucleosides imported by equilibrative nucleoside transporter 3 (ENT3) was analysed and, furthermore, a comprehensive analysis of the effect of exogenously fed nucleosides at the level of metabolic as well as transcriptomic alterations was performed. Expression of nucleoside transporters ENT1 and ENT3, together with nucleoside import, was increased upon nitrogen limitation. Thereby a role for ENT3, which is expressed mainly in the vasculature of roots and leaves, as a major import route for nucleosides was supported. Exogenously fed nucleosides were able to attenuate nitrogen starvation effects such as chlorophyll breakdown, anthocyanin accumulation, RNA breakdown and reduced levels of amino acids. In response to nucleoside supply, up‐regulation of genes involved in nitrogen distribution in plants was observed. In addition, genes involved in nucleoside metabolism were identified as regulated upon nitrogen limitation. In summary, an overall beneficial effect of nucleoside supply to Arabidopsis seedlings, especially under limiting nitrogen conditions, was observed.

Abstract-Process variations increasingly challenge the manufacturability of advanced devices and the yield of integrated circuits. Technology computer-aided design (TCAD) has the potential to make key contributions to minimize this problem, by assessing the impact of certain variations on the device, circuit, and system. In this way, TCAD can provide the information necessary to decide on investments in the processing level or the adoption of a more variation tolerant process flow, device architecture, or design on circuit or chip level. In this first of two consecutive papers, sources of process variations and the state of the art of related simulation tools are reviewed. An approach for hierarchical simulation of process variations including their correlations is presented. The second paper, also published in this issue, presents examples of simulation results obtained with this methodology.

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