Functional superparamagnetic core-shell nanoparticles are synthesized by a microwave assisted route and can be used as colloidal supports for peptide synthesis in "quasi solution".

Efficient routes to N-terminal PEGylated peptides are described. Alternative supports such as superparamagnetic core−shell nanoparticles as colloidal supports and end-functional poly(styrene) as homogeneous supports improve the available solid-phase supported coupling strategies preserving ease of purification. Poly(ethylene glycol) (PEG)−peptide bioconjugates are obtained in high yield despite the use of nearly stoichiometric PEGylation agents with respect to the supported peptides.

No abstract