Region of Epirus located in NW Greece, is an area, that many landslides are recorded every year and earthquakes had impact in the infrastructures and human’s life in the past. In order to assess the seismic and the landslide risk, a susceptibility map was created and validated based on the landslide recordings, using the Rock Engineering System (RES) method, buffer zones were also created for each fault that was selected and calculations using empirical mathematical formulas were used to examine the potential as well as the maximum and the average ground displacement and finally a geodatabase was developed. The landslide susceptibility map and buffer zones were examined in relation to the proximity of the settlements, the road network and the cultural monuments of the area and many useful conclusions were exported, as an initial effort of recording the built environment that could potentially be vulnerable and affected.