Increased awareness of the symptoms suggestive of intrauterine adhesive disease, as well as recognition of common causes and preceding events, is crucial for early diagnosis, patient counselling and treatment. VIDEO ABSTRACT: http://links.lww.com/COOG/A36.

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Summary All organisms have devised strategies to counteract energy depletion in order to promote fitness for survival. We show here that cellular energy depletion puts into play a surprising strategy that leads to absorption of exogenous fuel for energy repletion. We found that the energy depletion sensing kinase AMPK, binds, phosphorylates, and activates the transcriptional coactivator SRC-2, which in a liver-specific manner, promotes absorption of dietary fat from the gut. Hepatocyte-specific deletion of SRC-2 results in intestinal fat malabsorption and attenuated entry of fat into the blood stream. This defect can be attributed to AMPK and SRC-2 mediated transcriptional regulation of hepatic bile-acid secretion into the gut, as it can be completely rescued by replenishing intestinal BA, or by genetically restoring the levels of hepatic Bile Salt Export Pump (BSEP). Our results position the hepatic AMPK-SRC-2 axis as an energy rheostat which upon cellular energy depletion resets whole-body energy by promoting absorption of dietary fuel.