The
results of our process development studies to synthesize the
methanol solvate of (S)-omeprazole potassium salt
(1) through the enantioselective oxidation of pyrmetazole
(2) using (1R)-(−)-10-camphorsulfonyloxaziridine
(3) are reported. Optical purity enhancement was achieved
by means of a reslurry from methanol, the rationale and development
details of which are also described.
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