Chiral dirhodium(II) carboxamidates catalyze highly stereoselective hetero-Diels-Alder reactions of aromatic aldehydes with methyl-substituted Danishefsky's dienes with high turnover numbers. The methyl substituents of the diene influence both enantioselectivity in product formation and the rate of the reaction in the presence of chiral dirhodium(II) Lewis acids.
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