As instructional design professionals are being asked more frequently to develop interventions for global environments, they must account for many complex intercultural communication and corporate globalization strategy variables. Simple rules of etiquette and stereotypes about particular cultures are tempting but dangerous assumptions upon which to base the design and delivery of training for multicultural learners. On the other hand, a full understanding of the subtle cultural differences that could impact global training is beyond the expectations to which instructional designers could reasonably be held. A more sensible approach than trying to know all the answers is knowing what questions to ask in the needs analysis and assessment phases. Based on a synthesis of literature and instantiated by several short examples, a framework for identifying important issues for instructional design and delivery in global settings is presented.