In a large cohort of US healthcare personnel (HCP) without prior COVID-19 infection, 94,382 doses of mRNA COVID-19 vaccine were administered to 49,220 individuals. The adjusted vaccine effectiveness following two doses of each of the two available brands of mRNA vaccine exceeded 96%.

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We report the utility of rapid antigen tests (RAgT) in a cohort of US healthcare personnel with COVID-19 infection who met symptom criteria to return to work at day 5 or later of isolation. 11.9% of initial RAgT were negative. RAgT can be helpful to guide return to work decisions.