Whilst working on an upcoming meta-analysis that synthesized fifty years of research on predictors of programming performance, we made an interesting discovery. Despite several studies citing a motivation for research as the 'high failure rates of introductory programming courses', to date, the majority of available evidence on this phenomenon is at best anecdotal in nature, and only a single study by Bennedsen and Caspersen has attempted to determine a worldwide pass rate of introductory programming courses. In this paper, we answer the call for further substantial evidence on the CS1 failure rate phenomenon, by performing a systematic review of introductory programming literature, and a statistical analysis on pass rate data extracted from relevant articles. Pass rates describing the outcomes of 161 CS1 courses that ran in 15 different countries, across 51 institutions were extracted and analysed. An almost identical mean worldwide pass rate of 67.7% was found. Moderator analysis revealed significant, but perhaps not substantial differences in pass rates based upon: grade level, country, and class size. However, pass rates were found not to have significantly differed over time, or based upon the programming language taught in the course. This paper serves as a motivation for researchers of introductory programming education, and provides much needed quantitative evidence on the potential difficulties and failure rates of this course.

New antibiotics are needed to combat rising resistance, with new Mycobacterium tuberculosis (Mtb) drugs of highest priority. Conventional whole-cell and biochemical antibiotic screens have failed. We developed a novel strategy termed PROSPECT (PRimary screening Of Strains to Prioritize Expanded Chemistry and Targets) in which we screen compounds against pools of strains depleted for essential bacterial targets. We engineered strains targeting 474 Mtb essential genes and screened pools of 100-150 strains against activity-enriched and unbiased compounds libraries, measuring > 8.5-million chemical-genetic interactions. Primary screens identified > 10-fold more hits than screening wild-type Mtb alone, with chemical-genetic interactions providing immediate, direct target insight. We identified > 40 novel compounds targeting DNA gyrase, cell wall, tryptophan, folate biosynthesis, and RNA polymerase, as well as inhibitors of a novel target EfpA. Chemical optimization yielded EfpA inhibitors with potent wild-type activity, thus demonstrating PROSPECT's ability to yield inhibitors against novel targets which would have eluded conventional drug discovery.

Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. Abstract-The high failure rates of many programming courses means there is a need to identify struggling students as early as possible. Prior research has focused upon using a set of tests to assess the use of a student's demographic, psychological and cognitive traits as predictors of performance. But these traits are static in nature, and therefore fail to encapsulate changes in a student's learning progress over the duration of a course. In this paper we present a new approach for predicting a student's performance in a programming course, based upon analyzing directly logged data, describing various aspects of their ordinary programming behavior. An evaluation using data logged from a sample of 45 programming students at our University, showed that our approach was an excellent early predictor of performance, explaining 42.49% of the variance in coursework marks -double the explanatory power when compared to the closest related technique in the literature.