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HABP1 might be an independent predictive factor for breast cancer prognosis and up-regulation of HABP1 might play an important role in the metastasis of breast cancer.

a-Synuclein AggregationParkinson's disease a b s t r a c t Substantial evidence implicates that the aggregation of a-synuclein (aSyn) is a critical factor in the pathogenesis of Parkinson's disease. This study focuses on the role of aSyn C-terminus. We introduced two additional cysteine residues at positions 107 and 124 (A107C and A124C) to our previous construct. Five X-isomers of oxidative-folded mutation of a-synuclein with three disulfides were isolated and their secondary structures and aggregating features were analyzed. All isomers showed similar random coil structures as wild-type a-synuclein. However, these isomers did not form aggregates or fibrils, even with prolonged incubation, suggesting that the interactions between the C-terminal and N-terminal or central NAC region are important in maintaining the natively unfolded structure of aSyn and thus prevent aSyn from changing conformation, which is a critical step for fibrillation.Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.