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Background: With the promotion of human papillomavirus (HPV) vaccine, cervical cancer has become a current research hotspot, and lncRNA has been confirmed to be used in the research of different diseases. This article systematically expounds the regulation and potential mechanisms of HOXA cluster antisense RNA 3 (HOXA-AS3) in cervical cancer, and discusses its possibility as a prognostic biomarker for cervical cancer. Methods: Relative expression levels of HOXA-AS3 and miR-29a-3p in tissues and cells were determined by real-time quantitative polymerase chain reaction (RT-qPCR). The survival of cervical cancer patients was analyzed by Kaplan-Meier method and the cumulative survival function table was drawn. The proliferation, migration, and invasion levels of HOXA-AS3 in cells were detected according to cell counting kit-8 (CCK-8) and transwell method. The dual-luciferase reporter gene assay confirmed the mechanism of action between HOXA-AS3 and miR-29a-3p. Results: HOXA-AS3 was elevated and miR-29a-3p was decreased in tissues and cells of cervical cancer patients. Knockdown of HOXA-AS3 could inhibit the progression of cervical cancer and was more conducive to patient survival. Bioinformatics analysis confirmed that HOXA-AS3 negatively regulates cervical cancer development by sponging miR-29a-3p. Conclusion:In this research, knockdown of HOXA-AS3 could alleviate the process of cervical cancer by sponging miR-29a-3p, suggesting that HOXA-AS3 may be a potential prognostic target of cervical cancer, which could provide a theoretical basis for future clinical research of cervical cancer.

Emergent events of urban rail transit may cause train delay, even service disruption, and then lead to a large number of passengers stranded. Urban rail transit system is difficult to maintain normal operation, so passengers shall be transported through other traffic modes outside the station. Traffic management plan outside the station is analyzed and evaluated in advance, which can increase evacuation efficiency and reduce the influence of events on society. The plan is evaluated through analyzing and simulation. Firstly, this paper analyzes the influence of events on traffic outside the station and introduces common means of traffic management. Then, this paper studies integrated simulation method and chooses key evaluation indicators, thus use the order of preference by similarity to ideal solution to evaluate the traffic management plan based on simulation. Finally, taking Jiangsu Road station as an example, this paper evaluates the effectiveness of different plans by simulation, the evaluation results show that plan 2 (partial priority) is optimal, which provides a reference for urban rail transit emergency management.

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