Allium cepa Linn, botanicals, Liliaceae (family) commonly known as onion, and coffee are special delicacies, and conventional as functional foods that contain physiologically active ingredients that for centuries have been exploited as folk remedies for the treatment of diseases. The present study was conducted to evaluate the therapeutic efficacies and the possible participation of oxidative stress of Nigerian Allium cepa and coffee such as antioxidant, antihyperglycaemic, hypoglycaemic, hyperglycaemic in normal experimental wistar rats. Materials and Methods: qualitative phytochemical screening of hydromethanolic extract of Allium cepa was carried out for the identifications of the phytoconstituents. Hydromethanolic extract of Allium cepa 100mg kg -1, vitamin E 400mg kg -1, and coffee 500mg kg-1, combinations of Allium cepa and coffee and vitamin E and coffee respectively, administered orally to each group of rats daily. During the experimental periods glucose concentrations were estimated at baseline 0 (time of treatment ingestion), age 21 and 42 days respectively, with corresponded oxidative stress markers -superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and malondialdehyde (MDA) analyzed at age 42 days. Results:Result ranked time-dependent (in days) glucose lowering potential of treatments as: -Allium cepa + coffee > Allium cepa > vitamin E > coffee + vitamin E; with corresponded up regulated of SOD, CAT, GPx and GSH and reduced MDA. Conversely, coffee and control group (normal rats) significantly in time -dependent, raised blood glucose level with corresponded increase in MDA with respect to other biomarkers, suggesting lipid peroxidation oxidative stress induced impairment of cellular antioxidant protective system. Conclusion:It can be concluded that synergistic effect, presence of the additive bioactive phytoconstituents, and/or antioxidant efficacies or both, and potentiation action of several compounds in Allium cepa and coffee combined , over time, offer the intrinsic antioxidant defence system much better defensive mechanism to protect against free radicals, and alleviate the toxic effects of accumulation of reactive oxygen species (ROS); thence providing protective mechanisms against the development of elevated blood sugar levels. Evidently, Allium cepa and coffee combined is Research ArticleVolume 3 Issue 1

Despite the recent surge in demand for unripe banana products, there is a scarcity of literature regarding their potential health tendencies. This study investigated the various organic biomolecules, minerals and phytotherapeutic constituents in unripe M. sapientum pulp and peel extracts and their associated medicinal relevance. Hydromethanolic solvent (1:4 v/v) was used for extraction. Biochemical analysis of the various plant samples was done using standard laboratory protocols and separate detectors; GCMS and GCFID. Proximate and mineral analysis of unripe M. sapientum samples was compared to the corresponding ripe samples. The results showed the presence of functionally distinct predominant constituents in both studied unripe M. sapientum peel and pulp extracts, in which some of the constituents have several medicinal benefits. The study revealed the nutritional relevance of the unripe peel and pulp extract of M. sapientum