Garcinia kola has been confirmed for spermatogenic and tissue enhancing effect of testis in male wistar rats. This study was carried out to investigate the histological effect of ethanolic extract of Garcinia kola on Lead II oxide induced testicular damage. Thirty five (35) adult male wistar rats were randomly selected into seven (7) groups n=5. Group A received 0.5 ml saline solution, Group B received 100 mg/kg of Garcinia kola extract only, Group C received 5 mg/kg of Lead II oxide only, Group D 1 received 100 mg/kg of Garcinia kola extract and 5 mg/kg of Lead II oxide, Group D 2 received 200 mg/kg of Garcinia kola extract and 5 mg/kg of Lead II oxide, Group E received 500 mg/kg of vitamin E only and Group F received 500 mg/kg of vitamin E and 5 mg/kg Lead II oxide. Administration was done orogastrically daily for 2 weeks, animals were sacrificed 24 hours after the last administration by cervical dislocation and the testes excised following abdominal incision for histological observation using H/E stain. Slight degeneration of the germinal epithelium of the seminiferous tubule and abnormal widening of the interstitial space involving loss of Leydig were observed following the administration of Lead II oxide. However, Improvements in the testicular architecture were noticed in the rats treated with the Garcinia kola and the Vitamin E respectively thus histological integrity maintained.