Improving the tribological properties of Inconel 625 is of great significance for its application in slewing bearing and bearing parts of mechanical transmission system in nuclear power plants. In this study, the tribological properties of textured surface (GTSs) and smooth surface (SS-20) of Inconel 625 under different loads during dry sliding friction were researched. The results show that GTSs improves tribological properties of Inconel 625 obviously. The friction coefficient of GTSs is lower than that of SS-20. The grooves on GTSs play a role in capturing wear debris during the friction process, which improve the contact surface characteristics between counterpart ball and substrate, leading to the reduction in wear loss. When the load is 20 N, the Inconel 625 with textured surface has the best tribological performance. The excessive load will cause the big deformation of material and decrease the capacity of capturing wear debris of grooves, resulting in the accumulation of debris and the severe wear of wear track.