This study aimed to identify influences of depression, anxiety and stress-coping aspect upon smoking desire of undergraduates, depending on their lifestyles. Method had analyzed each measuring item in a way of structural equation of SPSS17.0/AMOS 5.0, then reliability analysis was conducted. The measuring items included health-conscious, fashion-conscious, grade-conscious, physical figure-conscious and convenience-conscious in students' lifestyles had correlation with depression, anxiety and stress-coping aspect. Also it was studied if their depression, anxiety and stress-coping aspect had influences upon smoking desire. The result showed that students health-conscious, grade-conscious, and physical figure-conscious had correlation with depression and anxiety, and among them, those health-conscious, grade-conscious, and physical figure-conscious had led to smoking desire. Conclusion showed that students' lifestyles may accompany depression and anxiety, ultimately causing smoking desire. Accordingly, this study can be consider to develop smoking prevention educational programs and policies.