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There is a dose-response relationship between the number of packs smoked per day and SUR in the striatum, and the frequency of hand tremor. Decreased dopamine transporter binding in the striatum and increased frequency of hand tremor in smokers may have important implications for evaluating the impact of smoking on the central and peripheral nerve systems.

A 65-year-old female had high fever, headache, and myalgia for 7 days. She also had a resting tremor, shuffling gait, and bradykinesia. Brain MRI showed no specifically abnormal finding. Tc-99m ethyl cysteinate dimer (ECD) brain perfusion scan showed moderately decreased cerebral perfusion in bilateral frontal and bilateral temporal regions. Tc-99m ͓2-͓͓2-͓͓͓3-(4-chlorophenyl)-8methyl-8-azabicyclo ͓3,2,1͔oct-2-yl͔methyl͔(2-mercaptoethyl)amino͔ ethyl͔amino͔ethanethiolato(3-)-N 2 ,N 2 Ј,S 2 ,S 2 Ј͔oxo-͓1R-(exo-exo)͔ (TRODAT) is a potential agent for imaging dopamine transporter that measures dopamine terminal innervation of the striatum. The Tc-99m TRODAT scan showed significantly decreased uptake in bilateral striata. IgM capture enzyme-linked immunoassay of serum and CSF were performed and showed Japanese encephalitis.Key Words: Japanese encephalitis, Tc-99m ethyl cysteinate dimer (ECD), Tc-99m ͓2-͓͓2-͓͓͓3-(4-chlorophenyl)-8-methyl-8azabicyclo ͓3,2,1͔oct-2-yl͔methyl͔(2-mercaptoethyl)amino͔ethyl͔ amino͔ethanethiolato(3-)-N2,N2Ј,S2,S2Ј͔oxo-͓1R-(exo-exo)͔ (TRODAT) (Clin Nucl Med 2007;32: 484 -485)

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