Electronic jamming is the key technology of electronic countermeasure, for which models and simulations are studied on noise jamming, deception jamming, and chaff jamming. In the noise jamming, the simulation analysis of radio frequency noise jamming is conducted and the theoretical models of other forms of noise jamming are built. The simulation analysis of range-gate pull off (RGPO) is carried out in the deception jamming. In addition, theoretical modeling and simulation analysis of chaff jamming are carried out with the Monte Carlo method. Simulation results show that the models are correct and can be used to simulate the statistical characteristics of chaff jamming. With the development and wide application of electronic technology, radar, communication, navigation, and IFF signals constitute a complex electromagnetic environment. It is a must to study electronic jamming technology in the complex electromagnetic environment, which will play an indispensable role in the construction of information team and victory in the countermeasure of information technology.

Cannabidiol (CBD) is a nonpsychoactive cannabinoid compound. It has been shown that CBD can inhibit the proliferation of ovarian cancer cells, but the underlying specific mechanism is unclear. We previously presented the first evidence for the expression of leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1), a member of the immunosuppressive receptor family, in ovarian cancer cells. In the present study, we investigated the mechanism by which CBD inhibits the growth of SKOV3 and CAOV3 ovarian cancer cells, and we sought to understand the concurrent role of LAIR-1. In addition to inducing ovarian cancer cell cycle arrest and promoting cell apoptosis, CBD treatment significantly affected the expression of LAIR-1 and inhibited the PI3K/AKT/mTOR signaling axis and mitochondrial respiration in ovarian cancer cells. These changes were accompanied by an increase in ROS, loss of mitochondrial membrane potential, and suppression of mitochondrial respiration and aerobic glycolysis, thereby inducing abnormal or disturbed metabolism and reducing ATP production. A combined treatment with N-acetyl-L-cysteine and CBD indicated that a reduction in ROS production would restore PI3K/AKT/mTOR pathway signaling and ovarian cancer cell proliferation. We subsequently confirmed that the inhibitory effect of CBD on the PI3K/AKT/mTOR signal axis and mitochondrial bioenergy metabolism was attenuated by knockdown of LAIR-1. Our animal studies further support the in vivo anti-tumor activity of CBD and suggest its mechanism of action. In summary, Li Ma and Huachang Zhang contributed equally to this study.

A continuous nonsingular fast terminal sliding mode (NFTSM) control scheme with the extended state observer (ESO) and the tracking differentiator (TD) is proposed for second-order uncertain SISO nonlinear systems. The system’s disturbances and states can be estimated by introducing the ESO, then the disturbances are compensated effectively, and the ideal transient process of the system can be arranged based on TD to provide the target tracking signal and its high-order derivatives. The proposed controller obtains finite-time convergence property and keeps good robustness of sliding mode control (SMC) for disturbances. Moreover, compared with conventional SMC, the proposed control law is continuous and no chattering phenomenon exists. The property of system stability is guaranteed by Lyapunov stability theory. The simulation results show that the proposed method can be employed to shorten the system reaching time, improve the system tracking precision, and suppress the system chattering and the input noise. The proposed control method is finally applied for the rotating control problem of theodolite servo system.

AimThe use of bevacizumab in combination therapy is an emerging trend in metastatic colorectal cancer treatment. However, the clinical value of different combination types remains under debate. Thus, a meta-analysis of randomized controlled trials (RCTs) comparing bevacizumab-based combination therapy with monotherapy (therapy that uses one type of treatment, such as chemotherapy or surgery alone, to treat metastatic colorectal cancer) was performed, aiming to evaluate the safety and efficacy of bevacizumab-based combination therapy and to find a more beneficial combination.MethodsWe searched for clinical studies that evaluated bevacizumab-based combination therapy in metastatic colorectal cancer. We extracted data from these studies to evaluate the relative risk (RR) of overall response rate (ORR) and grade 3/4 treatment-related adverse events (AEs), HRs of overall survival (OS), and progression-free survival (PFS).ResultsEight RCTs were identified (n=3,424). Treatments included combinations of bevacizumab and oxaliplatin, fluorouracil, and leucovorin (FOLFOX4), combinations of bevacizumab and capecitabine and oxaliplatin, combinations of bevacizumab and fluorouracil/leucovorin, combinations of bevacizumab and irinotecan, fluorouracil, and leucovorin (IFL), and combinations of bevacizumab and capecitabine. Bevacizumab-based combination therapy showed higher ORR (RR: 1.40; 95% CI: 1.10–1.78; P=0.005), PFS (HR: 0.64; 95% CI: 0.55–0.73; P=0.000), and OS (HR: 0.82; 95% CI: 0.73–0.92; P=0.001) values than monotherapy. However, higher grade 3/4 treatment-related AEs (RR: 1.27; 95% CI: 1.15–1.41; P=0.000) were observed in combination therapy than in monotherapy.ConclusionThis meta-analysis showed that the addition of IFL to bevacizumab better benefits PFS and safety. Adding FOLFOX4 was associated with better ORR and OS. The efficacy and safety of an IFL–bevacizumab–FOLFOX4 combination should be given greater weight in future clinical trials, guidelines, and clinical practice.