1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3‐methyl‐2‐ thiohydantoin in one patient. 3 Large interindividual differences were observed, especially within the carbimazole group. 4 Incomplete absorption of carbimazole could explain particular high apparent volumes of distribution and apparent clearances.

1 A high performance liquid chromatographic (HPLC) method was used to study the pharmacokinetics of methimazole after oral administration of carbimazole to women in various stages of pregnancy. 2 In one patient it was possible to conduct the study in the first and third timesters: there was an appreciable increase in the apparent clearance of methimazole. 3 Based on the assumption of complete absorption and hydrolysis of carbimazole to methimazole the mean apparent clearance was found to be significantly higher in pregnant patients receiving 10 mg carbimazole than in non‐pregnant patients receiving the same dose.

Background: Cosmetic rhinoplasty has great potential to change one's appearance. It also carries a very real risk for dissatisfaction and revision. While there have been many patient series published studying various aspects of rhinoplasty over the years, questions remain regarding rates of revision, as well as risk factors for complications, dissatisfaction, and revision surgery. Methods:We reviewed the charts of 384 consecutive cosmetic rhinoplasties performed by a single practice of plastic surgeons over a 10 year period. Full pre-operative and post-operative data were collected. Operative reports were reviewed for details including approach, anesthesia, grafts, sutures, skeletal and cartilage reshaping, and any soft tissue modification. All possible associations were analyzed for statistical significance.