2-Methyleneaziridines can be transformed into a variety of 1,3,4,4-tetrasubstituted beta-lactams in moderate to good yields (46-63%) via a "one-pot" process that brings together four components with the formation of three new intermolecular carbon-carbon bonds.

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In Europe, contact photosensitivity to phenothiazines is known particularly in southern countries. Topical phenothiazines are widely used and sold over-the-counter for the treatment of mosquito bites and pruritus in France. Objective:To report a series of cases with photodermatitis to topical phenothiazines. Method:A retrospective study of cases of contact dermatitis to phenothiazines seen in French photodermatology centres was performed. Results:In all, 14 patients with the diagnosis of contact dermatitis to phenothiazines were included. These developed eczema on the application sites, and in 13 the eruption spread to photodistributed sites. Topical products containing isothipendyl were the most common cause of photodermatitis. One patient had photoaggravated eczema due to promethazine cream. All patients stopped using topical phenothiazines and were treated successfully with topical corticosteroids. One patient relapsed and developed persistent light eruption. In all of the 9 cases tested, photopatch testing to the topical phenothiazine used "as is" was positive.Isothipendyl, chlorproethazine and the excipients were not tested. Photopatch tests to chlorpromazine and promethazine were positive in 8/12 and 7/13 tested respectively. Conclusion:Use of isothipendyl and promethazine as over-the-counter (or even prescribed) drugs needs to be limited due to severe reactions and sensitization to other phenothiazines that otherwise will have to be avoided.

A Hetero Diels-Alder Approach to the Synthesis of the First Angucyclinone and Angucycline 5-Aza-analogues. -The (E,E)-heterodienes (IV) are subjected to [4 + 2]cycloaddition reactions with several bromonaphthoquinones (VI) to give angucyclinone 5-aza analogues regioselectively. This protocol is further applied to the C-glycoside (IX). -(COLLET, S. C.; REMI, J.-F.; CARIOU, C.; LAIB, S.; GUINGANT, A. Y.; NGUYEN QUANG VU; DUJARDIN, G.; Tetrahedron Lett. 45