Nesidioblastosis is an exceedingly rare occurrence in the adult and, when it appears, it is usually part of a MEAl syndrome. We present a .case of nesidioblastosis in a young woman, with no concurrent endocrine pathology, while we discuss in detail the diagnostic and therapeutic problems posed by this condition. The selected treatment was sub-total pancreatectomy (70-80%) and the histopathologic and immunohistochemical tests of the surgical specimen showed:"Diffuse Nesidioblastosis'.The histopathologic and immuno-histochemical features of the resected pancreas are analysed in detail.

Pulmonary epitheloid hemangioendothelioma (PEHE) is a rare, often incidentally diagnosed, endothelial tumor of the lung. We present a case of a young adult who presented with acute hypoxemic respiratory failure and severe pulmonary hypertension with subsequent imaging and tissue biopsy confirming a diagnosis of PEHE. We briefly highlight the unique clinical, radiographic and histopathologic aspects of this rare disease. We propose that PEHE should be considered in the differential diagnosis for acute hypoxemic respiratory failure associated with bilateral pulmonary cavitary nodules and bronchoscopy should be considered as an initial diagnostic test.

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