Myocardial infarction results in a massive loss of cardiomyocytes (CMs). Unfortunately, current therapies are unsuccessful in replacing lost CMs, and thus, there is an urgent need for innovative approaches. Here, a nanosystem based on spermine‐acetalated dextran (AcDXSp) and encapsulating two drug compounds able to stimulate in vitro CMs proliferation is developed. The nanosystem is coated by deposition of a film constituted by tannic acid (TA) and Fe3+ ions. The coating with TA increases the retention of the nanocarrier in cell co‐cultures of CMs and fibroblasts stimulated with transforming growth factor (TGF)‐β, due to the high affinity of TA for components of the cardiac extracellular matrix. The system exhibits biocompatibility toward primary CMs and induces their proliferation, as indicated by the two‐fold increase of CMs in the active cell cycle. At the same time, the presence of TA synergistically helps contrasting fibrosis by reducing profibrotic genes expression, such as collagen 1 and osteopontin, by approximately 80% compared to the control. Overall, the developed nanosystem demonstrates the capability to stimulate CMs proliferation and reduce fibrosis, showing potential benefits for future in vivo applications.

A statistical survey on the pathology and rehabilitation of linoleum and vinyl floorings is presented. It is based on the visual inspection of 101 vinyl and linoleum floorings, in six health infrastructures in Lisbon, Portugal, which enabled the validation of the classification/nomenclature previously proposed, as well as the corresponding correlation matrices. It was also possible to identify the most common types of anomalies, their probable causes, the most adequate in situ diagnosis methods, and the most useful repair techniques. Anomalies, diagnosis methods, and repair techniques files were also validated. The obtained data enabled anomalies to be related to their causes, in situ diagnosis methods, and respective repair techniques e.g., a high number of scratches/wear were detected associated with dragging of equipment. The conclusions drawn intend to raise awareness among the industry actors and minimize the development of anomalies and their causes at the design and application stages. Furthermore, the main sensitive issues of the cladding system during its service life were revealed, highlighting the importance of a correct maintenance plan to minimize the surface’s susceptibility to various degradation mechanisms.

No abstract