INTRODUCTION: Chagas disease (ChD) is a chronic illness related to significant morbidity and mortality that can affect the quality of life (QoL) of infected patients. However, there are few studies regarding QoL in ChD. The objectives of this study are to construct a health-related QoL (HRQoL) profile of ChD patients and compare this with a non-ChD (NChD) group to identify factors associated with the worst HRQoL scores in ChD patients. METHODS: HRQoL was investigated in 125 patients with ChD and 21 NChD individuals using the Medical Outcomes Study 36-item Short-Form (SF-36) and the Minnesota Living with Heart Failure Questionnaire (MLWHFQ). Patients were submitted to a standard protocol that included clinical examination, ECG, Holter monitoring, Doppler echocardiogram and autonomic function tests. RESULTS: HRQoL scores were significantly worse among the ChD group compared to the NChD group in the SF-36 domains of physical functioning and role-emotional and in the MLWHFQ scale. For the ChD group, univariate analysis showed that HRQoL score quartiles were associated with level of education, sex, marital status, use of medication, functional classification and cardiovascular and gastrointestinal symptoms. In the multivariate analysis, female sex, fewer years of education, single status, worst functional classification, presence of cardiovascular and gastrointestinal symptoms, associated illnesses, Doppler echocardiographic abnormalities and ventricular arrhythmia detected during Holter monitoring were predictors of lower HRQoL scores. CONCLUSIONS: ChD patients showed worse HRQoL scores compared to NChD. For the ChD group, sociodemographic and clinical variables were associated with worst scores.
OBJETIVO: Avaliar o efeito do treinamento com exercício aeróbio na capacidade funcional (CF) e no controle da pressão arterial (PA), em mulheres na pós-menopausa, hipertensas estágio I, controladas ou não com tratamento medicamentoso, em uma Unidade Básica de Saúde (UBS). METODOLOGIA: Antes e após 12 semanas de treinamento com exercício aeróbio em uma UBS, dez mulheres hipertensas na pós-menopausa, idade de 56,9 ± 6 anos, sedentárias, não usuárias de terapia de reposição hormonal, foram submetidas à avaliação do índice de massa corporal (IMC); da circunferência da cintura (CC); da CF pelo teste ergométrico (maior consumo de oxigênio/ VO2 e tempo de teste) e teste de caminhada em seis minutos (distância caminhada); e das medidas casuais repetidas da PA. Reavaliações foram efetuadas a cada 30 dias. Os dados são expressos em média e desvio-padrão. Foram aplicados os testes de Kolmogorov-Smirnov, t de Student pareado, Wilcoxon e ANOVA para medidas repetidas, considerando significativo p < 0,05. RESULTADOS: Não houve diferença significativa no IMC (p = 0,40) e CC (p = 0,74) após a intervenção. Entretanto, após 30 dias observou-se redução da PA sistólica (de 142,70 ± 6,25 para 130,76 ± 5,80 mmHg, p < 0,001) e diastólica (de 87,03 ± 4,48 para 81,90 ± 4,30 mmHg, p = 0,002) e melhora da CF pelo VO2 (de 24,90 ± 6,38 para 27,82 ± 6,14 mL/kg/min, p = 0,028), tempo de teste (de 6,89 ± 1,78 para 7,7 ± 1,8 min, p = 0,022) e distância caminhada (de 511,07 ± 41,99 para 556,1 ± 43,19 m, p = 0,009). CONCLUSÃO: O programa de treinamento com exercício aeróbio em uma UBS mostrou-se efetivo e viável, contribuindo para a redução da PA e melhora da capacidade funcional em mulheres hipertensas na pós-menopausa.
In clinically stable patients receiving conventional cardiac pacing, the intraventricular dyssynchrony was an independent predictor of BNP level increase after adjusted for age and LVEF.
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