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Obesity among children has emerged as a serious public health problem. The growing prevalence of childhood obesity has led to the appearance of serious complications, including a chronic systemic inflammation associated with oxidative stress. In the present study, we analysed the interaction between two genes related with iron metabolism -HFE and haptoglobin -and the plasmatic concentration of glutathione, as a way to evaluate the antioxidant response capacity in obesity. To achieve this, 118 obese children and 89 eutrophic children were recruited for the study. Results showed that although obese children present a significantly decreased tGSH levels, once we analysed separately children based on their haptoglobin phenotype, the decreased tGSH levels is significant only for the Hp 2 allele. Additionally, Hp 2.2 obese children carrying H63D polymorphism show significantly lower tGSH/GSSG values. Our results found an association of haptoglobin and HFE with oxidative stress in childhood obesity.

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Media production and consumption behaviors are changing in response to new technologies and demands, giving birth to a new generation of social applications. Among them, crowd journalism represents a novel way of constructing democratic and trustworthy news relying on ordinary citizens arriving at breaking news locations and capturing relevant videos using their smartphones. To address this need, the ARTICONF project proposes a trustworthy, resilient, and globally sustainable toolset for developing decentralized applications (DApps). Its goal is to overcome the privacy, trust, and autonomy-related concerns associated with proprietary social media platforms overflowed by fake news. Leveraging the ARTICONF tools, we introduce a new DApp for crowd journalism called MOGPlay. MOGPlay collects and manages audio-visual content generated by citizens and provides a secure blockchain platform that rewards all stakeholders involved in professional news production. Besides live streaming, MOGPlay offers a marketplace for audio-visual content trading among citizens and free journalists with an internal token ecosystem. We discuss the functionality and implementation of the MOGPlay DApp and illustrate four pilot crowd journalism live scenarios that validate the prototype.