A cDNA clone coding for human protein kinase CKI (casein kinase 1) has been isolated and sequenced demonstrating that it corresponds to a homolog of the CKla form found in bovine brain. The derived amino acid sequence of the human CKlcl is identical to the bovine counterpart except that it contains I2 extra amino acids at the carboxyl end. Using this cDNA sequence and PCR amplification, YAC genomic clones that contain this human CKla sequence have been isolated. These YACs have been used for fluorescent in situ hybridization in order to localize the human CKla gene to chromosome 13q13.

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