The potential effects of stem cell-released microvesicles (MVs) in proangiogenic therapy were explored. MVs were released from adipose-derived stem cells (ASCs) and were able to increase the migration and tube formation of human umbilical vein endothelial cells. MVs from ASCs, particularly from endothelial differentiation medium-preconditioned ASCs, were found to have elevated levels of microRNA-31 and to promote angiogenesis.
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