Background and Purpose-The purpose of this research was to investigate the impact of lesion location on motor excitability and motor performance. Methods-We studied patients with pure motor strokes in 4 different brain areas: motor cortex lesions (nϭ7), striatocapsular lesions (nϭ13), lacunar lesions of the internal capsule (nϭ13), and paramedian pontine lesions (nϭ10). Motor performance tests included the 9-hole-peg test and grip strength recordings. Motor excitability was determined by transcranial magnetic stimulation. Motor thresholds, stimulus-response curves, silent periods, motor cortical inhibition, and facilitation were investigated. Results-The 4 groups were clinically similar but showed major differences in motor excitability. Only motor cortex lesions had a loss of intracortical inhibition in the affected hemisphere. In the internal capsule lesion group and the pontine lesion group, stimulus-response curves were depressed on the affected side. All of the subcortical lesions showed a prolongation of the silent period in the paretic side. Motor thresholds were predominantly elevated in the lesioned hemisphere of patients with internal capsule or pontine lesions. Motor performance was correlated with silent period duration in internal capsule lesions and with motor thresholds in internal capsule and pontine lesions.
Conclusions-Motor
Die saisonale Influenza ist eine akute, impfpräventable respiratorische Erkrankung, die durch das Influenzavirus (RNA, Orthomyxoviridae) verursacht wird [1]. Die Grippewelle der Saison 2017/2018 war die schwerste seit dem Jahr 2001 [2]. Etwa 65,0 % der nachgewiesenen Influenzainfektionen waren vom Influenza Typ B und gehörten fast ausschließlich der Yamagata-Linie an [2]. Die B-Komponente des während der Influenzasaison überwiegend genutzten, trivalenten Influenzaimpfstoffes basierte auf der Victoria-Linie und bot daher keinen hinreichenden Schutz vor einer Infektion mit der Yamagata-Linie. In der Influenzasaison 2017/2018 wurden in Deutschland etwa 9.000.000 zusätzliche influenzabedingte Arztkonsultationen und 45.000 Hospitalisierungen berichtet. Neben den Die Autoren C. Kraef und M. v. d. Meirschen habenzugleichenTeilenbeigetragen.
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