Keywords: dibenzylidenecyclohexanone; MAOS; eco-friendly ABSTRAK Telah dilakukan sintesis dibenzilidensikloheksanon dan turunannya melalui reaksi kondensasi aldol silang yang ramah lingkungan menggunakan metode MAOS. Sintesis dibenzilidensikloheksanon (8b) dilakukan melalui reaksi kondensasi antara benzaldehida 4 dan sikloheksanon 2 dalam krus porselen dengan rasio mol 2:1 menggunakan katalis natrium hidroksida selama 2 menit di dalam microwave. Turunan benzaldehida yang digunakan adalah 4-metoksibenzaldehida dan 3,4-dimetoksibenzaldehida untuk mensintesis (2E,6E)-bis(4-metoksibenziliden) siklo heksanon (8a) dan (2E,6E)-bis (3,4-dimetoksibenziliden)sikloheksanon (8c

Melinjo (Gnetum gnemon L.) peel has been known as antioxidant, antibacterial, and antifungal, but not yet used as cosmetic ingredients or drugs optimally. This research focuses on the production of organic soap bars from melinjo peel extract, the quality testing, and antimicrobial analysis against selected microbes. The soap making process was done by the saponification reaction between the mixture of palm oil and coconut oil with sodium hydroxide through cold and hot processes. Distilled water and ethanol were used as solvents for melinjo peel extraction. The quality test was done by determining insoluble fraction in ethanol, free alkali, and unsaponified fatty matter. An antimicrobial activity test was conducted using the Kirby-Bauer diffusion method. The result shows that the quality test fit with INS 2016 for all the criteria except for unsaponified fatty acid in the cold process soap bar. Inhibition zone of organic soap bar sequentially decreased against the growth of Tricophytone mentagrophytes, Staphylococcus aureus, and Staphylococcus epidermidis. Therefore, the organic soap bar with melinjo peel extract shows a good potential to be used as an antimicrobial soap.

Synthesis of  amyl vanillyl ether from vanillin was carried out by two different methods, two-steps reaction method and one-step  reaction method. In two-steps reaction method beginning with the first stage reduction of vanillin with NaBH4 to obtain vanillyl alcohol. Then, dehydration vanillyl alcohol and amyl alcohol with concentrated sulfuric acid. Synthesized compound were identification by TLC, IR spectroscopy  and GCMS. In one step reaction method the vanillyl alcohol  as a result of reduction of vanillin with NaBH4 are not isolated in advance, immediately reacted with amyl alcohol to form  amyl vanillyl ether compound with concentrated HCl dehydrator. The results of two-steps reaction method showed that the reduction reaction of vanillin with NaBH4 produced vanillyl alcohol. Vanillyl alcohol compound that produced is white powder and yield 41.28%. Vanillyl amyl ether compound could not synthesis by dehydration from vanillyll alcohol from reduction of vanillin and amyl alcohol. Ether compound from dehydration of vanillyl alcohol from reduction of vanillin and amyl alcohol is diamyl ethers. Method one reaction step successfully synthesized amyl vanilil ether compound. Amyl vanilil ether compound that produced  is liquid, colorless and yield 86.42%. Keywords: amyl vanillil ether, vanillin, vanillil alcohol, amyl alcohol

Penelitian ini bertujuan untuk mensintesis senyawa sinamil benzoat melalui reaksi esterifikasi antara asam asetat dengan sinamil alkohol hasil reduksi sinamaldehida. Penelitian dimulai dengan mereduksi sinamaldehida menjadi sinamil alkohol menggunakan reduktor NaBH4 pada suhu kamar. Kemudian  hasil reduksi sinamaldehida direaksikan dengan benzoil klorida dan piridina pada suhu kamar selama 4 jam. Senyawa hasil reduksi sinamaldehida dan hasi reaksi esterifikasi diidentifikasi dengan menggunakan KLT, Spektrofotometer IR, dan spektrofotometer GC-MS. Hasil penelitian menunjukkan bahwa reduksi sinamaldehida menghasilkan cairan berwarna kuning jerami yang mengandung sinamil alkohol dengan kadar 81,31% dan rendemen 63,94%. Hasil reaksi esterifikasi antara benzoil klorida dan sinamil alkohol menghasilkan cairan cokelat yang mengandung sinamil benzoat dengan kadar 12,44% dan rendemen 5,78%.