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The emergence of antibiotics-resistant bacteria has been a serious concern for medical professionals over the last decade. Therefore, developing new and effective antimicrobials with modified or different modes of action is a continuing imperative. In this context, our study focuses on evaluating the antimicrobial activity of different chemically synthesized flavonoids (FLAV) to guide the chemical synthesis of effective antimicrobial molecules. A set of 12 synthesized molecules (4 chalcones, 4 flavones and 4 flavanones), bearing substitutions with chlorine and bromine groups at the C6′ position and methoxy group at the C4′ position of the B-ring were evaluated for antimicrobial activity toward 9 strains of Gram-positive and Gram-negative bacteria and 3 fungal strains. Our findings showed that most tested FLAV exhibited moderate to high antibacterial activity, particularly against Staphylococcus aureus with minimum inhibitory concentrations (MIC) between the range of 31.25 and 125 μg/mL and that chalcones were more efficient than flavones and flavanones. The examined compounds were also active against the tested fungi with a strong structure-activity relationship (SAR). Interestingly, leakage measurements of the absorbent material at 260 nm and scanning electron microscopy (SEM) demonstrated that the brominated chalcone induced a significant membrane permeabilization of S. aureus.

This study was carried out in six (6) communes of Abidjan within a period of six months (November 2016 to April 2017). This paper focuses on assessing the microbiological quality of traditional medicines produced and sold in these communes. A total of 38 samples were collected, including 19 in powder form and another 19 in liquid form. The search and enumeration of the germs was carried out according to the method based on standard procedures (AFNOR). Enumeration included total mesophilic aerobic flora, total coliforms, yeasts and molds, Staphylococcus aureus, and salmonella. The results indicate an absence of the pathogenic flora (Salmonella and S. aureus). There is also an absence of yeasts and molds in the products in liquid form. The level of contamination of the Mesophilic Total Aerobic Flora (FMAT) ranges from 1.104 to 6.7.107 CFU / ml or CFU / g and from 1.6.104 to 5.5.107 CFU / g or CFU / ml for total coliforms. In terms of microbiological quality, 39.47% of the analyzed samples had compliant. In view of these results, it is necessary to train Traditional Medicine Practitioners on Good Manufacturing Practices (GMP) methods throughout the production chain in order to market MTAs of guaranteed quality and safety

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